IMPORTANT SAFETY INFORMATION Obagi Nu-Derm Clear, Blender and Sunfader (contains 4% hydroquinone) CONTRAINDICATIONS: People with prior history of sensitivity or allergic reaction to this product or any of its ingredients should not use it. The safety of topical hydroquinone use during pregnancy or in children (12 years and under) has not been established. Please see full Prescribing Information for Clear, Blender and Sunfader WARNINGS: Avoid contact with eyes, nose, mouth, or lips. In case of accidental contact, patient should rinse eyes, nose, mouth, or lips with water and contact physician. Sunscreen use is an essential aspect of hydroquinone therapy because even minimal sunlight exposure sustains melanocytic activity. Contains sodium metabisulfite, a sulfite that may cause allergic-type reactions including anaphylactic symptoms and life-threatening or less severe asthmatic episodes in certain susceptible people. The overall prevalence of sulfite sensitivity in the general population is unknown and probably low. Sulfite sensitivity is seen more frequently in asthmatic than in nonasthmatic people. PRECAUTIONS (ALSO SEE WARNINGS): Treatment should be limited to relatively small areas of the body at one time since some patients experience a transient skin reddening and a mild burning sensation, which does not preclude treatment. Pregnancy Category C: Animal reproduction studies have not been conducted with topical hydroquinone. It is also not known whether hydroquinone can cause fetal harm when used topically on a pregnant woman or affect reproductive capacity. It is not known to what degree, if any, topical hydroquinone is absorbed systemically. Topical hydroquinone should be used on pregnant women only when clearly indicated. Nursing Mothers: It is not known whether topical hydroquinone is absorbed or excreted in human milk. Caution is advised when topical hydroquinone is used by a nursing mother. Pediatric Usage: Safety and effectiveness in children below the age of 12 years have not been established. Use of the product should be discontinued if hypersensitivity to any of the ingredients is noted.

Hydroquinone 4% Strong inhibitor of melanin production that has long been established as the most effective ingredient for reducing and potentially eliminating melasma. Each gram of Obagi Nu-Derm Clear contains the following ingredients. Active Ingredient: hydroquinone, USP 4% (40 mg/g) Inactive Ingredients: ascorbic acid, BHT, butylparaben, cetyl alcohol, disodium EDTA, glycerin, lactic acid, methylparaben, phenyl trimethicone, PPG-2 myristyl ether propionate, propylparaben, saponins, sodium lauryl sulfate, sodium metabisulfite, TEA-stearyl alcohol, tocopheryl acetate, water (aqua)

Use daily, in the morning and evening. Squeeze a small amount (approximately 1-2 pea-size amounts) onto your hand. Apply evenly to the entire face, extending to the hairline, over the ears, and ending with a feathering motion, or as directed by your physician. If no improvement is seen after three (3) months of treatment, use of this product should be discontinued.

Store at controlled room temperature: 15ºC–25°C (59°F–77°F) Keep out of direct sunlight

IMPORTANT SAFETY INFORMATION Obagi Nu-Derm Clear, Blender and Sunfader (contains 4% hydroquinone) CONTRAINDICATIONS: People with prior history of sensitivity or allergic reaction to this product or any of its ingredients should not use it. The safety of topical hydroquinone use during pregnancy or in children (12 years and under) has not been established. Please see full Prescribing Information for Clear, Blender and Sunfader WARNINGS: Avoid contact with eyes, nose, mouth, or lips. In case of accidental contact, patient should rinse eyes, nose, mouth, or lips with water and contact physician. Sunscreen use is an essential aspect of hydroquinone therapy because even minimal sunlight exposure sustains melanocytic activity. Contains sodium metabisulfite, a sulfite that may cause allergic-type reactions including anaphylactic symptoms and life-threatening or less severe asthmatic episodes in certain susceptible people. The overall prevalence of sulfite sensitivity in the general population is unknown and probably low. Sulfite sensitivity is seen more frequently in asthmatic than in nonasthmatic people. PRECAUTIONS (ALSO SEE WARNINGS): Treatment should be limited to relatively small areas of the body at one time since some patients experience a transient skin reddening and a mild burning sensation, which does not preclude treatment. Pregnancy Category C: Animal reproduction studies have not been conducted with topical hydroquinone. It is also not known whether hydroquinone can cause fetal harm when used topically on a pregnant woman or affect reproductive capacity. It is not known to what degree, if any, topical hydroquinone is absorbed systemically. Topical hydroquinone should be used on pregnant women only when clearly indicated. Nursing Mothers: It is not known whether topical hydroquinone is absorbed or excreted in human milk. Caution is advised when topical hydroquinone is used by a nursing mother. Pediatric Usage: Safety and effectiveness in children below the age of 12 years have not been established. Use of the product should be discontinued if hypersensitivity to any of the ingredients is noted.

Hydroquinone 4% Strong inhibitor of melanin production that has long been established as the most effective ingredient for reducing and potentially eliminating melasma. Each gram of Obagi Nu-Derm Blender contains the following ingredients. Active Ingredient: hydroquinone, USP 4% (40 mg/g) Inactive Ingredients: ascorbic acid, BHT, cetyl alcohol, disodium EDTA, glycerin, lactic acid, methylparaben, phenyl trimethicone, PPG-2 myristyl ether propionate, propylparaben, saponins, sodium lauryl sulfate, sodium metabisulfite, TEA-salicylate, tocopheryl acetate, water (aqua)

Use daily, in the evening. Squeeze a small amount (approximately 1-2 pea-size drops) onto your hand. Apply evenly to the entire face, or as directed by your skin care physician. If no improvement is seen after three (3) months of treatment, use of this product should be discontinued.

Store at controlled room temperature: 15°–25°C (59°–77°F) Keep out of direct sunlight

Hydroquinone 4% Strong inhibitor of melanin production that has long been established as the most effective ingredient for reducing and potentially eliminating melasma. Each gram of Obagi Nu-Derm Sunfader contains the following ingredients. Active Ingredient: hydroquinone, USP 4% (40 mg/g); octinoxate, USP 7.5%; oxybenzone, USP 5.5% Inactive Ingredients: ascorbic acid, BHT, butylparaben, cetyl alcohol, disodium EDTA, glycerin, methylparaben, propylparaben, saponins, sodium lauryl sulfate, sodium metabisulfite, stearyl alcohol, tocopheryl acetate, water (aqua)

Hydroquinone 4% Strong inhibitor of melanin production that has long been established as the most effective ingredient for reducing and potentially eliminating melasma. Each gram of Obagi Nu-Derm Sunfader contains the following ingredients. Active Ingredient: hydroquinone, USP 4% (40 mg/g); octinoxate, USP 7.5%; oxybenzone, USP 5.5% Inactive Ingredients: ascorbic acid, BHT, butylparaben, cetyl alcohol, disodium EDTA, glycerin, methylparaben, propylparaben, saponins, sodium lauryl sulfate, sodium metabisulfite, stearyl alcohol, tocopheryl acetate, water (aqua)

A thin application should be applied once or twice daily or as directed by a physician.

Store at controlled room temperature: 15°C–25°C (59°F–77°F) Keep out of direct sunlight

The Nu-Derm Rx System - Normal to Oily comes with Obagi Nu-Derm Foaming Gel, Obagi Nu-Derm Toner Obagi Nu-Derm Clear, Obagi Nu-Derm Exfoderm Forte, Obagi Nu-Derm Blender, Obagi Hydrate Facial Moisturizer, Sun Shield Matte Broad Spectrum SPF 50

The Nu-Derm Rx System - Normal to Dry comes with Obagi Nu-Derm Gentle Cleanser, Obagi Nu-Derm Toner, Obagi Nu-Derm Clear Obagi Nu-Derm Exfoderm, Obagi Nu-Derm Blender, Obagi Hydrate Facial Moisturizer, Sun Shield Matte Broad Spectrum SPF 50

The Nu-Derm Rx Trial Kit - Normal to Oily comes with Obagi Nu-Derm Foaming Gel (2 oz), Obagi Nu-Derm Toner (2 oz), Obagi Nu-Derm Clear (2 oz), Obagi Nu-Derm Exfoderm Forte (1 oz), Obagi Nu-Derm Blender (2 oz), Sun Shield Matte Broad Spectrum SPF 50 (1 oz)

The Nu-Derm Rx Trial Kit - Normal to Dry comes with Obagi Nu-Derm Gentle Cleanser (2 oz), Obagi Nu-Derm Toner (2 oz), Obagi Nu-Derm Clear (2 oz), Obagi Nu-Derm Exfoderm (1 oz), Obagi Nu-Derm Blender (2 oz), Sun Shield™ Matte Broad Spectrum SPF 50 (1 oz)