IMPORTANT SAFETY INFORMATION Obagi-C Rx C-Clarifying Serum and C-Therapy Night Cream (contains 4% hydroquinone) CONTRAINDICATIONS: People with prior history of sensitivity or allergic reaction to this product or any of its ingredients should not use it. The safety of topical hydroquinone use during pregnancy or in children (12 years and under) has not been established. Please see full Prescribing Information for C-Clarifying Serum and C-Therapy Night Cream WARNINGS: Avoid contact with eyes, nose, mouth, or lips. In case of accidental contact, patient should rinse eyes, nose, mouth, or lips with water and contact physician. Sunscreen use is an essential aspect of hydroquinone therapy because even minimal sunlight exposure sustains melanocytic activity. Contains sodium metabisulfite, a sulfite that may cause allergic-type reactions including anaphylactic symptoms and life-threatening or less severe asthmatic episodes in certain susceptible people. The overall prevalence of sulfite sensitivity in the general population is unknown and probably low. Sulfite sensitivity is seen more frequently in asthmatic than in nonasthmatic people. PRECAUTIONS: Treatment should be limited to relatively small areas of the body at one time since some patients experience a transient skin reddening and a mild burning sensation, which does not preclude treatment. Pregnancy Category C: Animal reproduction studies have not been conducted with topical hydroquinone. It is also not known whether hydroquinone can cause fetal harm when used topically on a pregnant woman or affect reproductive capacity. It is not known to what degree, if any, topical hydroquinone is absorbed systemically. Topical hydroquinone should be used on pregnant women only when clearly indicated. Nursing Mothers: It is not known whether topical hydroquinone is absorbed or excreted in human milk. Caution is advised when topical hydroquinone is used by a nursing mother. Pediatric Usage: Safety and effectiveness in children below the age of 12 years have not been established. Use of the product should be discontinued if hypersensitivity to any of the ingredients is noted.

Hydroquinone 4% strong inhibitor of melanin production that has long been established as the most effective ingredient for reducing and potentially eliminating melasma. L-ascorbic Acid 10% known as the purest form of Vitamin C, L-ascorbic acid helps neutralize free radicals, minimize the look of fine lines and wrinkles, and brighten skin tone. Active Ingredient: Hydroquinone USP, 4% (40 mg/g). Inactive Ingredients: Propylene glycol, water (aqua), ascorbic acid, propylene carbonate, sodium lauryl sulfate

Use once daily in the morning. Apply 5 to 7 drops to the entire face or as directed by your skin care physician, massage in gently.

Store at controlled room temperature: 15°C–25°C (59°F–77°F) Keep out of direct sunlight

IMPORTANT SAFETY INFORMATION Obagi-C Rx C-Clarifying Serum and C-Therapy Night Cream (contains 4% hydroquinone) CONTRAINDICATIONS: People with prior history of sensitivity or allergic reaction to this product or any of its ingredients should not use it. The safety of topical hydroquinone use during pregnancy or in children (12 years and under) has not been established. Please see full Prescribing Information for C-Clarifying Serum and C-Therapy Night Cream WARNINGS: Avoid contact with eyes, nose, mouth, or lips. In case of accidental contact, patient should rinse eyes, nose, mouth, or lips with water and contact physician. Sunscreen use is an essential aspect of hydroquinone therapy because even minimal sunlight exposure sustains melanocytic activity. Contains sodium metabisulfite, a sulfite that may cause allergic-type reactions including anaphylactic symptoms and life-threatening or less severe asthmatic episodes in certain susceptible people. The overall prevalence of sulfite sensitivity in the general population is unknown and probably low. Sulfite sensitivity is seen more frequently in asthmatic than in nonasthmatic people. PRECAUTIONS: Treatment should be limited to relatively small areas of the body at one time since some patients experience a transient skin reddening and a mild burning sensation, which does not preclude treatment. Pregnancy Category C: Animal reproduction studies have not been conducted with topical hydroquinone. It is also not known whether hydroquinone can cause fetal harm when used topically on a pregnant woman or affect reproductive capacity. It is not known to what degree, if any, topical hydroquinone is absorbed systemically. Topical hydroquinone should be used on pregnant women only when clearly indicated. Nursing Mothers: It is not known whether topical hydroquinone is absorbed or excreted in human milk. Caution is advised when topical hydroquinone is used by a nursing mother. Pediatric Usage: Safety and effectiveness in children below the age of 12 years have not been established. Use of the product should be discontinued if hypersensitivity to any of the ingredients is noted.

Hydroquinone 4% strong inhibitor of melanin production that has long been established as the most effective ingredient for reducing and potentially eliminating melasma. L-ascorbic Acid 10% known as the purest form of Vitamin C, L-ascorbic acid helps neutralize free radicals, minimize the look of fine lines and wrinkles, and brighten skin tone. Active Ingredient: Hydroquinone USP, 4% (40 mg/g). Inactive Ingredients: Propylene glycol, water (aqua), ascorbic acid, propylene carbonate, sodium lauryl sulfate

Use once daily in the morning. Apply 5 to 7 drops to the entire face or as directed by your skin care physician, massage in gently.

Store at controlled room temperature: 15°C–25°C (59°F–77°F) Keep out of direct sunlight

IMPORTANT SAFETY INFORMATION Obagi-C Rx C-Clarifying Serum and C-Therapy Night Cream (contains 4% hydroquinone) CONTRAINDICATIONS: People with prior history of sensitivity or allergic reaction to this product or any of its ingredients should not use it. The safety of topical hydroquinone use during pregnancy or in children (12 years and under) has not been established. Please see full Prescribing Information for C-Clarifying Serum and C-Therapy Night Cream WARNINGS: Avoid contact with eyes, nose, mouth, or lips. In case of accidental contact, patient should rinse eyes, nose, mouth, or lips with water and contact physician. Sunscreen use is an essential aspect of hydroquinone therapy because even minimal sunlight exposure sustains melanocytic activity. Contains sodium metabisulfite, a sulfite that may cause allergic-type reactions including anaphylactic symptoms and life-threatening or less severe asthmatic episodes in certain susceptible people. The overall prevalence of sulfite sensitivity in the general population is unknown and probably low. Sulfite sensitivity is seen more frequently in asthmatic than in nonasthmatic people. PRECAUTIONS: Treatment should be limited to relatively small areas of the body at one time since some patients experience a transient skin reddening and a mild burning sensation, which does not preclude treatment. Pregnancy Category C: Animal reproduction studies have not been conducted with topical hydroquinone. It is also not known whether hydroquinone can cause fetal harm when used topically on a pregnant woman or affect reproductive capacity. It is not known to what degree, if any, topical hydroquinone is absorbed systemically. Topical hydroquinone should be used on pregnant women only when clearly indicated. Nursing Mothers: It is not known whether topical hydroquinone is absorbed or excreted in human milk. Caution is advised when topical hydroquinone is used by a nursing mother. Pediatric Usage: Safety and effectiveness in children below the age of 12 years have not been established. Use of the product should be discontinued if hypersensitivity to any of the ingredients is noted.

Hydroquinone 4% strong inhibitor of melanin production that has long been established as the most effective ingredient for reducing and potentially eliminating melasma. Active Ingredient: Hydroquinone USP, 4% (40mg/g). Inactive Ingredients: Water (aqua), glycerin, cetyl alcohol, PPG-2 myristyl ether propianate, sodium lauryl sulfate, TEA-salicylate, latic acid, phenyl trimethicone, tocopheryl acetate, sodium metabisulfite, ascorbic acid, methylparben, disodium EDTA, propylparaben, saponins, BHT

A thin application should be applied once or twice daily or as directed by a physician. If no improvement is seen after three (3) months of treatment, use of this product should be discontinued.

Store at controlled room temperature: 15ºC–25°C (59°F–77°F) Keep out of direct sunlight

The Obagi-C Rx System - Normal to Dry comes with C-Cleansing Gel, C-Clarifying Serum Normal to Dry, C-Exfoliating Day Lotion, C-Therapy Night Cream, Rx Only, Sun Shield Matte Broad Spectrum SPF 50

The Obagi-C Rx System - Normal to Oily comes with C-Cleansing Gel, C-Clarifying Serum Normal to Oily, C-Therapy Night Cream, Sun Shield Matte Broad Spectrum SPF 50