Obagi-C® Rx

IMPORTANT SAFETY INFORMATION Obagi Nu-Derm Clear, Blender and Sunfader (contains 4% hydroquinone) CONTRAINDICATIONS: People with prior history of sensitivity or allergic reaction to this product or any of its ingredients should not use it. The safety of topical hydroquinone use during pregnancy or in children (12 years and under) has not been established. Please see full Prescribing Information for Clear, Blender and Sunfader WARNINGS: Avoid contact with eyes, nose, mouth, or lips. In case of accidental contact, patient should rinse eyes, nose, mouth, or lips with water and contact physician. Sunscreen use is an essential aspect of hydroquinone therapy because even minimal sunlight exposure sustains melanocytic activity. Contains sodium metabisulfite, a sulfite that may cause allergic-type reactions including anaphylactic symptoms and life-threatening or less severe asthmatic episodes in certain susceptible people. The overall prevalence of sulfite sensitivity in the general population is unknown and probably low. Sulfite sensitivity is seen more frequently in asthmatic than in nonasthmatic people. PRECAUTIONS (ALSO SEE WARNINGS): Treatment should be limited to relatively small areas of the body at one time since some patients experience a transient skin reddening and a mild burning sensation, which does not preclude treatment. Pregnancy Category C: Animal reproduction studies have not been conducted with topical hydroquinone. It is also not known whether hydroquinone can cause fetal harm when used topically on a pregnant woman or affect reproductive capacity. It is not known to what degree, if any, topical hydroquinone is absorbed systemically. Topical hydroquinone should be used on pregnant women only when clearly indicated. Nursing Mothers: It is not known whether topical hydroquinone is absorbed or excreted in human milk. Caution is advised when topical hydroquinone is used by a nursing mother. Pediatric Usage: Safety and effectiveness in children below the age of 12 years have not been established. Use of the product should be discontinued if hypersensitivity to any of the ingredients is noted.

Hydroquinone 4% Strong inhibitor of melanin production that has long been established as the most effective ingredient for reducing and potentially eliminating melasma. Each gram of Obagi Nu-Derm Clear contains the following ingredients. Active Ingredient: hydroquinone, USP 4% (40 mg/g) Inactive Ingredients: ascorbic acid, BHT, butylparaben, cetyl alcohol, disodium EDTA, glycerin, lactic acid, methylparaben, phenyl trimethicone, PPG-2 myristyl ether propionate, propylparaben, saponins, sodium lauryl sulfate, sodium metabisulfite, TEA-stearyl alcohol, tocopheryl acetate, water (aqua)

Use daily, in the morning and evening. Squeeze a small amount (approximately 1-2 pea-size amounts) onto your hand. Apply evenly to the entire face, extending to the hairline, over the ears, and ending with a feathering motion, or as directed by your physician. If no improvement is seen after three (3) months of treatment, use of this product should be discontinued.

Store at controlled room temperature: 15ºC–25°C (59°F–77°F) Keep out of direct sunlight

IMPORTANT SAFETY INFORMATION Obagi Nu-Derm Clear, Blender and Sunfader (contains 4% hydroquinone) CONTRAINDICATIONS: People with prior history of sensitivity or allergic reaction to this product or any of its ingredients should not use it. The safety of topical hydroquinone use during pregnancy or in children (12 years and under) has not been established. Please see full Prescribing Information for Clear, Blender and Sunfader WARNINGS: Avoid contact with eyes, nose, mouth, or lips. In case of accidental contact, patient should rinse eyes, nose, mouth, or lips with water and contact physician. Sunscreen use is an essential aspect of hydroquinone therapy because even minimal sunlight exposure sustains melanocytic activity. Contains sodium metabisulfite, a sulfite that may cause allergic-type reactions including anaphylactic symptoms and life-threatening or less severe asthmatic episodes in certain susceptible people. The overall prevalence of sulfite sensitivity in the general population is unknown and probably low. Sulfite sensitivity is seen more frequently in asthmatic than in nonasthmatic people. PRECAUTIONS (ALSO SEE WARNINGS): Treatment should be limited to relatively small areas of the body at one time since some patients experience a transient skin reddening and a mild burning sensation, which does not preclude treatment. Pregnancy Category C: Animal reproduction studies have not been conducted with topical hydroquinone. It is also not known whether hydroquinone can cause fetal harm when used topically on a pregnant woman or affect reproductive capacity. It is not known to what degree, if any, topical hydroquinone is absorbed systemically. Topical hydroquinone should be used on pregnant women only when clearly indicated. Nursing Mothers: It is not known whether topical hydroquinone is absorbed or excreted in human milk. Caution is advised when topical hydroquinone is used by a nursing mother. Pediatric Usage: Safety and effectiveness in children below the age of 12 years have not been established. Use of the product should be discontinued if hypersensitivity to any of the ingredients is noted.

Hydroquinone 4% Strong inhibitor of melanin production that has long been established as the most effective ingredient for reducing and potentially eliminating melasma. Each gram of Obagi Nu-Derm Blender contains the following ingredients. Active Ingredient: hydroquinone, USP 4% (40 mg/g) Inactive Ingredients: ascorbic acid, BHT, cetyl alcohol, disodium EDTA, glycerin, lactic acid, methylparaben, phenyl trimethicone, PPG-2 myristyl ether propionate, propylparaben, saponins, sodium lauryl sulfate, sodium metabisulfite, TEA-salicylate, tocopheryl acetate, water (aqua)

Use daily, in the evening. Squeeze a small amount (approximately 1-2 pea-size drops) onto your hand. Apply evenly to the entire face, or as directed by your skin care physician. If no improvement is seen after three (3) months of treatment, use of this product should be discontinued.

Store at controlled room temperature: 15°–25°C (59°–77°F) Keep out of direct sunlight

Hydroquinone 4% Strong inhibitor of melanin production that has long been established as the most effective ingredient for reducing and potentially eliminating melasma. Each gram of Obagi Nu-Derm Sunfader contains the following ingredients. Active Ingredient: hydroquinone, USP 4% (40 mg/g); octinoxate, USP 7.5%; oxybenzone, USP 5.5% Inactive Ingredients: ascorbic acid, BHT, butylparaben, cetyl alcohol, disodium EDTA, glycerin, methylparaben, propylparaben, saponins, sodium lauryl sulfate, sodium metabisulfite, stearyl alcohol, tocopheryl acetate, water (aqua)

Hydroquinone 4% Strong inhibitor of melanin production that has long been established as the most effective ingredient for reducing and potentially eliminating melasma. Each gram of Obagi Nu-Derm Sunfader contains the following ingredients. Active Ingredient: hydroquinone, USP 4% (40 mg/g); octinoxate, USP 7.5%; oxybenzone, USP 5.5% Inactive Ingredients: ascorbic acid, BHT, butylparaben, cetyl alcohol, disodium EDTA, glycerin, methylparaben, propylparaben, saponins, sodium lauryl sulfate, sodium metabisulfite, stearyl alcohol, tocopheryl acetate, water (aqua)

A thin application should be applied once or twice daily or as directed by a physician.

Store at controlled room temperature: 15°C–25°C (59°F–77°F) Keep out of direct sunlight

The Nu-Derm Rx Trial Kit - Normal to Oily comes with Obagi Nu-Derm Foaming Gel (2 oz), Obagi Nu-Derm Toner (2 oz), Obagi Nu-Derm Clear (2 oz), Obagi Nu-Derm Exfoderm Forte (1 oz), Obagi Nu-Derm Blender (2 oz), Sun Shield Matte Broad Spectrum SPF 50 (1 oz)

The Nu-Derm Rx Trial Kit - Normal to Dry comes with Obagi Nu-Derm Gentle Cleanser (2 oz), Obagi Nu-Derm Toner (2 oz), Obagi Nu-Derm Clear (2 oz), Obagi Nu-Derm Exfoderm (1 oz), Obagi Nu-Derm Blender (2 oz), Sun Shield™ Matte Broad Spectrum SPF 50 (1 oz)

The Nu-Derm Rx System - Normal to Oily comes with Obagi Nu-Derm Foaming Gel, Obagi Nu-Derm Toner Obagi Nu-Derm Clear, Obagi Nu-Derm Exfoderm Forte, Obagi Nu-Derm Blender, Obagi Hydrate Facial Moisturizer, Sun Shield Matte Broad Spectrum SPF 50

The Nu-Derm Rx System - Normal to Dry comes with Obagi Nu-Derm Gentle Cleanser, Obagi Nu-Derm Toner, Obagi Nu-Derm Clear Obagi Nu-Derm Exfoderm, Obagi Nu-Derm Blender, Obagi Hydrate Facial Moisturizer, Sun Shield Matte Broad Spectrum SPF 50

For Topical Use Only INDICATION: Tretinoin Gel is indicated for topical application in the treatment of acne vulgaris. CONTRAINDICATION: Use of the product should be discontinued if hypersensitivity to any of the ingredients is noted. Please see full Prescribing Information for Tretinoin Gel Precautions: Exposure to sunlight, including sunlamps, should be minimized during the use of Tretinoin Cream and Gel, and patients with sunburn should be advised not to use the product until fully recovered. Patients who have considerable sun exposure due to occupation and those with inherent sensitivity to the sun should exercise particular caution. Use of sunscreen products and protective clothing over treated areas is recommended when exposure cannot be avoided. Weather extremes, such as wind or cold, also may be irritating to patients using tretinoin. Tretinoin Gel should be kept away from the eyes, the mouth, angles of the nose, and mucous membranes. Topical use may induce severe local erythema and peeling at the site of application. If the degree of local irritation warrants, patients should be directed to use the medication less frequently, discontinue use temporarily, or discontinue use altogether. Tretinoin has been reported to cause severe irritation on eczematous skin and should be used with utmost caution in patients with this condition. Pregnancy: Tretinoin should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Adverse Reactions: The skin of certain sensitive individuals may become excessively red, edematous, blistered, or crusted. If these effects occur, treatment should be discontinued or adjusted to a level the patient can tolerate. To report SUSPECTED ADVERSE REACTIONS contact FDA at fda.gov/medwatch or call 1-800-FDA-1088.

Active Ingredient: 0.05% Tretinoin Derived from Vitamin A in the form of retinoic acid, the active ingredient tretinoin is a retinoid, widely recognized in skin care as a powerful and effective acne treatment. Contains micronized tretinoin in an aqueous gel composed of purified water, glycerin, and soluble collagen. Soluble collagen comprises methylparaben, propylparaben, ethylparaben, butylparaben, isobutylparaben, phenoxyethanol, fish collagen, and water. Each gram contains: Tretinoin Gel is a translucent to opaque, pale yellow gel containing 0.05% tretinoin, by weight. Other components of this formulation are benzyl alcohol, butylparaben, butylated hydroxytoluene, carbomer homopolymer Type C, ethylparaben, fish collagen hydrolyzates, glycerin, isobutylparaben, methylparaben, octoxynol 9, phenoxyethanol, propylparaben, purified water, sodium hyaluronate, and trolamine

Morning Routine: Apply a moisturizer, preferably with sunscreen, that will not aggravate your acne. Nighttime Routine: Wash with a mild soap and dry skin gently. Wait 20 to 30 minutes to allow skin to completely dry. Squeeze no more than half an inch of medication onto fingertip; more medication will not yield faster or better results and may cause irritation. Apply onto face, covering affected area lightly, starting with your forehead, chin, and both cheeks, then spread over the entire affected area. Avoid corners of the nose, mouth, eyes, and open wounds.

Store tretinoin gel 0.05% at controlled room temperature 20° - 25°C (68° - 77°F) with excursions permitted between 15°-30°C (59° - 86°F) Protect from freezing

For Topical Use Only INDICATION: Tretinoin Cream is indicated for topical application in the treatment of acne vulgaris. CONTRAINDICATION: Use of the product should be discontinued if hypersensitivity to any of the ingredients is noted. Please see full Prescribing Information for Tretinoin Cream PRECAUTIONS: Exposure to sunlight, including sunlamps, should be minimized during the use of Tretinoin Cream and Gel, and patients with sunburn should be advised not to use the product until fully recovered. Patients who have considerable sun exposure due to occupation and those with inherent sensitivity to the sun should exercise particular caution. Use of sunscreen products and protective clothing over treated areas is recommended when exposure cannot be avoided. Weather extremes, such as wind or cold, also may be irritating to patients using tretinoin. Tretinoin Cream should be kept away from the eyes, the mouth, angles of the nose, and mucous membranes. Topical use may induce severe local erythema and peeling at the site of application. If the degree of local irritation warrants, patients should be directed to use the medication less frequently, discontinue use temporarily, or discontinue use altogether. Tretinoin has been reported to cause severe irritation on eczematous skin and should be used with utmost caution in patients with this condition. Pregnancy: Tretinoin should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Adverse Reactions: The skin of certain sensitive individuals may become excessively red, edematous, blistered, or crusted. If these effects occur, treatment should be discontinued or adjusted to a level the patient can tolerate. To report SUSPECTED ADVERSE REACTIONS contact FDA at fda.gov/medwatch or call 1-800-FDA-1088.

Active Ingredient: 0.025% Tretinoin Derived from Vitamin A in the form of retinoic acid, the active ingredient tretinoin is a retinoid, widely recognized in skin care as a powerful and effective acne treatment. Each gram contains: Tretinoin 0.025%, stearic acid, isopropyl myristate, polyoxyl 40 stearate, stearyl alcohol, xanthan gum, sorbic acid, butylated hydroxytoluene, and purified water

Morning Routine: Apply a moisturizer, preferably with sunscreen, that will not aggravate your acne. Nighttime Routine: Wash with a mild soap and dry skin gently. Wait 20 to 30 minutes to allow skin to completely dry. Squeeze no more than half an inch of medication onto fingertip; more medication will not yield faster or better results and may cause irritation. Apply onto face, covering affected area lightly, starting with your forehead, chin, and both cheeks, then spread over the entire affected area. Avoid corners of the nose, mouth, eyes, and open wounds.

Store tretinoin cream at controlled room temperature below 80°F

For Topical Use Only INDICATION: Tretinoin Cream is indicated for topical application in the treatment of acne vulgaris. CONTRAINDICATION: Use of the product should be discontinued if hypersensitivity to any of the ingredients is noted. Please see full Prescribing Information for Tretinoin Cream PRECAUTIONS: Exposure to sunlight, including sunlamps, should be minimized during the use of Tretinoin Cream and Gel, and patients with sunburn should be advised not to use the product until fully recovered. Patients who have considerable sun exposure due to occupation and those with inherent sensitivity to the sun should exercise particular caution. Use of sunscreen products and protective clothing over treated areas is recommended when exposure cannot be avoided. Weather extremes, such as wind or cold, also may be irritating to patients using tretinoin. Tretinoin Cream should be kept away from the eyes, the mouth, angles of the nose, and mucous membranes. Topical use may induce severe local erythema and peeling at the site of application. If the degree of local irritation warrants, patients should be directed to use the medication less frequently, discontinue use temporarily, or discontinue use altogether. Tretinoin has been reported to cause severe irritation on eczematous skin and should be used with utmost caution in patients with this condition. Pregnancy: Tretinoin should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Adverse Reactions: The skin of certain sensitive individuals may become excessively red, edematous, blistered, or crusted. If these effects occur, treatment should be discontinued or adjusted to a level the patient can tolerate. To report SUSPECTED ADVERSE REACTIONS contact FDA at fda.gov/medwatch or call 1-800-FDA-1088.

Active Ingredient: 0.05% Tretinoin Derived from Vitamin A in the form of retinoic acid, the active ingredient tretinoin is a retinoid, widely recognized in skin care as a powerful and effective acne treatment. Each gram contains: Tretinoin 0.05%, stearic acid, isopropyl myristate, polyoxyl 40 stearate, stearyl alcohol, xanthan gum, sorbic acid, butylated hydroxytoluene, and purified water

Morning Routine: Apply a moisturizer, preferably with sunscreen, that will not aggravate your acne. Nighttime Routine: Wash with a mild soap and dry skin gently. Wait 20 to 30 minutes to allow skin to completely dry. Squeeze no more than half an inch of medication onto fingertip; more medication will not yield faster or better results and may cause irritation. Apply onto face, covering affected area lightly, starting with your forehead, chin, and both cheeks, then spread over the entire affected area. Avoid corners of the nose, mouth, eyes, and open wounds.

Store tretinoin cream at controlled room temperature below 80°F

For Topical Use Only INDICATION: Tretinoin Cream is indicated for topical application in the treatment of acne vulgaris. CONTRAINDICATION: Use of the product should be discontinued if hypersensitivity to any of the ingredients is noted. Please see full Prescribing Information for Tretinoin Cream PRECAUTIONS: Exposure to sunlight, including sunlamps, should be minimized during the use of Tretinoin Cream and Gel, and patients with sunburn should be advised not to use the product until fully recovered. Patients who have considerable sun exposure due to occupation and those with inherent sensitivity to the sun should exercise particular caution. Use of sunscreen products and protective clothing over treated areas is recommended when exposure cannot be avoided. Weather extremes, such as wind or cold, also may be irritating to patients using tretinoin. Tretinoin Cream should be kept away from the eyes, the mouth, angles of the nose, and mucous membranes. Topical use may induce severe local erythema and peeling at the site of application. If the degree of local irritation warrants, patients should be directed to use the medication less frequently, discontinue use temporarily, or discontinue use altogether. Tretinoin has been reported to cause severe irritation on eczematous skin and should be used with utmost caution in patients with this condition. Pregnancy: Tretinoin should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Adverse Reactions: The skin of certain sensitive individuals may become excessively red, edematous, blistered, or crusted. If these effects occur, treatment should be discontinued or adjusted to a level the patient can tolerate. To report SUSPECTED ADVERSE REACTIONS contact FDA at fda.gov/medwatch or call 1-800-FDA-1088.

Active Ingredient: 0.1% Tretinoin Derived from Vitamin A in the form of retinoic acid, the active ingredient tretinoin is a retinoid, widely recognized in skin care as a powerful and effective acne treatment. Each gram contains: Tretinoin 0.1%, stearic acid, isopropyl myristate, polyoxyl 40 stearate, stearyl alcohol, xanthan gum, sorbic acid, butylated hydroxytoluene, and purified water

Morning Routine: Apply a moisturizer, preferably with sunscreen, that will not aggravate your acne. Nighttime Routine: Wash with a mild soap and dry skin gently. Wait 20 to 30 minutes to allow skin to completely dry. Squeeze no more than half an inch of medication onto fingertip; more medication will not yield faster or better results and may cause irritation. Apply onto face, covering affected area lightly, starting with your forehead, chin, and both cheeks, then spread over the entire affected area. Avoid corners of the nose, mouth, eyes, and open wounds.

Store tretinoin cream at controlled room temperature below 80°F

IMPORTANT SAFETY INFORMATION Obagi-C Rx C-Clarifying Serum and C-Therapy Night Cream (contains 4% hydroquinone) CONTRAINDICATIONS: People with prior history of sensitivity or allergic reaction to this product or any of its ingredients should not use it. The safety of topical hydroquinone use during pregnancy or in children (12 years and under) has not been established. Please see full Prescribing Information for C-Clarifying Serum and C-Therapy Night Cream WARNINGS: Avoid contact with eyes, nose, mouth, or lips. In case of accidental contact, patient should rinse eyes, nose, mouth, or lips with water and contact physician. Sunscreen use is an essential aspect of hydroquinone therapy because even minimal sunlight exposure sustains melanocytic activity. Contains sodium metabisulfite, a sulfite that may cause allergic-type reactions including anaphylactic symptoms and life-threatening or less severe asthmatic episodes in certain susceptible people. The overall prevalence of sulfite sensitivity in the general population is unknown and probably low. Sulfite sensitivity is seen more frequently in asthmatic than in nonasthmatic people. PRECAUTIONS: Treatment should be limited to relatively small areas of the body at one time since some patients experience a transient skin reddening and a mild burning sensation, which does not preclude treatment. Pregnancy Category C: Animal reproduction studies have not been conducted with topical hydroquinone. It is also not known whether hydroquinone can cause fetal harm when used topically on a pregnant woman or affect reproductive capacity. It is not known to what degree, if any, topical hydroquinone is absorbed systemically. Topical hydroquinone should be used on pregnant women only when clearly indicated. Nursing Mothers: It is not known whether topical hydroquinone is absorbed or excreted in human milk. Caution is advised when topical hydroquinone is used by a nursing mother. Pediatric Usage: Safety and effectiveness in children below the age of 12 years have not been established. Use of the product should be discontinued if hypersensitivity to any of the ingredients is noted.

Hydroquinone 4% strong inhibitor of melanin production that has long been established as the most effective ingredient for reducing and potentially eliminating melasma. L-ascorbic Acid 10% known as the purest form of Vitamin C, L-ascorbic acid helps neutralize free radicals, minimize the look of fine lines and wrinkles, and brighten skin tone. Active Ingredient: Hydroquinone USP, 4% (40 mg/g). Inactive Ingredients: Propylene glycol, water (aqua), ascorbic acid, propylene carbonate, sodium lauryl sulfate

Use once daily in the morning. Apply 5 to 7 drops to the entire face or as directed by your skin care physician, massage in gently.

Store at controlled room temperature: 15°C–25°C (59°F–77°F) Keep out of direct sunlight

IMPORTANT SAFETY INFORMATION Obagi-C Rx C-Clarifying Serum and C-Therapy Night Cream (contains 4% hydroquinone) CONTRAINDICATIONS: People with prior history of sensitivity or allergic reaction to this product or any of its ingredients should not use it. The safety of topical hydroquinone use during pregnancy or in children (12 years and under) has not been established. Please see full Prescribing Information for C-Clarifying Serum and C-Therapy Night Cream WARNINGS: Avoid contact with eyes, nose, mouth, or lips. In case of accidental contact, patient should rinse eyes, nose, mouth, or lips with water and contact physician. Sunscreen use is an essential aspect of hydroquinone therapy because even minimal sunlight exposure sustains melanocytic activity. Contains sodium metabisulfite, a sulfite that may cause allergic-type reactions including anaphylactic symptoms and life-threatening or less severe asthmatic episodes in certain susceptible people. The overall prevalence of sulfite sensitivity in the general population is unknown and probably low. Sulfite sensitivity is seen more frequently in asthmatic than in nonasthmatic people. PRECAUTIONS: Treatment should be limited to relatively small areas of the body at one time since some patients experience a transient skin reddening and a mild burning sensation, which does not preclude treatment. Pregnancy Category C: Animal reproduction studies have not been conducted with topical hydroquinone. It is also not known whether hydroquinone can cause fetal harm when used topically on a pregnant woman or affect reproductive capacity. It is not known to what degree, if any, topical hydroquinone is absorbed systemically. Topical hydroquinone should be used on pregnant women only when clearly indicated. Nursing Mothers: It is not known whether topical hydroquinone is absorbed or excreted in human milk. Caution is advised when topical hydroquinone is used by a nursing mother. Pediatric Usage: Safety and effectiveness in children below the age of 12 years have not been established. Use of the product should be discontinued if hypersensitivity to any of the ingredients is noted.

Hydroquinone 4% strong inhibitor of melanin production that has long been established as the most effective ingredient for reducing and potentially eliminating melasma. L-ascorbic Acid 10% known as the purest form of Vitamin C, L-ascorbic acid helps neutralize free radicals, minimize the look of fine lines and wrinkles, and brighten skin tone. Active Ingredient: Hydroquinone USP, 4% (40 mg/g). Inactive Ingredients: Propylene glycol, water (aqua), ascorbic acid, propylene carbonate, sodium lauryl sulfate

Use once daily in the morning. Apply 5 to 7 drops to the entire face or as directed by your skin care physician, massage in gently.

Store at controlled room temperature: 15°C–25°C (59°F–77°F) Keep out of direct sunlight

IMPORTANT SAFETY INFORMATION Obagi-C Rx C-Clarifying Serum and C-Therapy Night Cream (contains 4% hydroquinone) CONTRAINDICATIONS: People with prior history of sensitivity or allergic reaction to this product or any of its ingredients should not use it. The safety of topical hydroquinone use during pregnancy or in children (12 years and under) has not been established. Please see full Prescribing Information for C-Clarifying Serum and C-Therapy Night Cream WARNINGS: Avoid contact with eyes, nose, mouth, or lips. In case of accidental contact, patient should rinse eyes, nose, mouth, or lips with water and contact physician. Sunscreen use is an essential aspect of hydroquinone therapy because even minimal sunlight exposure sustains melanocytic activity. Contains sodium metabisulfite, a sulfite that may cause allergic-type reactions including anaphylactic symptoms and life-threatening or less severe asthmatic episodes in certain susceptible people. The overall prevalence of sulfite sensitivity in the general population is unknown and probably low. Sulfite sensitivity is seen more frequently in asthmatic than in nonasthmatic people. PRECAUTIONS: Treatment should be limited to relatively small areas of the body at one time since some patients experience a transient skin reddening and a mild burning sensation, which does not preclude treatment. Pregnancy Category C: Animal reproduction studies have not been conducted with topical hydroquinone. It is also not known whether hydroquinone can cause fetal harm when used topically on a pregnant woman or affect reproductive capacity. It is not known to what degree, if any, topical hydroquinone is absorbed systemically. Topical hydroquinone should be used on pregnant women only when clearly indicated. Nursing Mothers: It is not known whether topical hydroquinone is absorbed or excreted in human milk. Caution is advised when topical hydroquinone is used by a nursing mother. Pediatric Usage: Safety and effectiveness in children below the age of 12 years have not been established. Use of the product should be discontinued if hypersensitivity to any of the ingredients is noted.

Hydroquinone 4% strong inhibitor of melanin production that has long been established as the most effective ingredient for reducing and potentially eliminating melasma. Active Ingredient: Hydroquinone USP, 4% (40mg/g). Inactive Ingredients: Water (aqua), glycerin, cetyl alcohol, PPG-2 myristyl ether propianate, sodium lauryl sulfate, TEA-salicylate, latic acid, phenyl trimethicone, tocopheryl acetate, sodium metabisulfite, ascorbic acid, methylparben, disodium EDTA, propylparaben, saponins, BHT

A thin application should be applied once or twice daily or as directed by a physician. If no improvement is seen after three (3) months of treatment, use of this product should be discontinued.

Store at controlled room temperature: 15ºC–25°C (59°F–77°F) Keep out of direct sunlight

The Obagi-C Rx System - Normal to Dry comes with C-Cleansing Gel, C-Clarifying Serum Normal to Dry, C-Exfoliating Day Lotion, C-Therapy Night Cream, Rx Only, Sun Shield Matte Broad Spectrum SPF 50

The Obagi-C Rx System - Normal to Oily comes with C-Cleansing Gel, C-Clarifying Serum Normal to Oily, C-Therapy Night Cream, Sun Shield Matte Broad Spectrum SPF 50