medical
Obagi Nu-Derm® Blender
Obagi Nu-Derm® Blender
Effective prescription 4% hydroquinone that helps correct hyperpigmentation, such as dark spots, sun spots, age spots, melasma, and other types of discoloration, for a healthier-looking, more even skin tone.
Prescription required. Contact your healthcare provider to purchase, or find a nearby physician who offers this product.
Skin Type: Dry Skin, Normal Skin, Oily Skin
Skin Concerns: Hyperpigmentation and Melasma, Skin Discoloration
Brightening Cream
- Size 2.0 oz

A unique formula containing prescription 4% hydroquinone for the gradual lightening of hyperpigmentation, such as dark spots, sun spots, age spots, melasma, and other types of discoloration.
With a 30-year legacy of science and innovation, Obagi has led transformative research that has met the needs of every skin tone and type. We believe skin care is more than “correcting” or even “preventing,” it’s about unleashing your skin’s full potential. That’s why at Obagi we create inclusive products that support the diversity we all bring to the table. It’s about developing scientifically backed, clinical-quality formulations to promote healthy, future-facing skin.
NEED TO KNOW
Important Safety Information for Clear, Blender and Sunfader (contains 4% hydroquinone)
CONTRAINDICATIONS: People with prior history of sensitivity or allergic reaction to this product or any of its ingredients should not use it. The safety of topical hydroquinone use during pregnancy or in children (12 years and under) has not been established.
Please see Prescribing Information for Clear, Blender and Sunfader
WARNINGS: Avoid contact with eyes, nose, mouth, or lips. In case of accidental contact, patient should rinse eyes, nose, mouth, or lips with water and contact physician.
Sunscreen use is an essential aspect of hydroquinone therapy because even minimal sunlight exposure sustains melanocytic activity.
Contains sodium metabisulfite, a sulfite that may cause allergic-type reactions including anaphylactic symptoms and life-threatening or less severe asthmatic episodes in certain susceptible people. The overall prevalence of sulfite sensitivity in the general population is unknown and probably low. Sulfite sensitivity is seen more frequently in asthmatic than in nonasthmatic people.
PRECAUTIONS (ALSO SEE WARNINGS): Treatment should be limited to relatively small areas of the body at one time since some patients experience a transient skin reddening and a mild burning sensation, which does not preclude treatment.
Pregnancy Category C: Animal reproduction studies have not been conducted with topical hydroquinone. It is also not known whether hydroquinone can cause fetal harm when used topically on a pregnant woman or affect reproductive capacity. It is not known to what degree, if any, topical hydroquinone is absorbed systemically. Topical hydroquinone should be used on pregnant women only when clearly indicated.
Nursing Mothers: It is not known whether topical hydroquinone is absorbed or excreted in human milk. Caution is advised when topical hydroquinone is used by a nursing mother.
Pediatric Usage: Safety and effectiveness in children below the age of 12 years have not been established.
Use of the product should be discontinued if hypersensitivity to any of the ingredients is noted.
Hydroquinone 4%
Strong inhibitor of melanin production that has long been established as the most effective ingredient for reducing and potentially eliminating melasma
Each gram of Obagi Nu-Derm Blender contains the following ingredients.
Active Ingredient: Hydroquinone, USP 4% (40 mg/g)
Inactive Ingredients: Ascorbic acid, BHT, cetyl alcohol, disodium EDTA, glycerin, lactic acid, methylparaben, phenyl trimethicone, PPG-2 myristyl ether propionate, propylparaben, saponins, sodium lauryl sulfate, sodium metabisulfite, TEA-salicylate, tocopheryl acetate, water (aqua)
- Use daily, in the evening.
- Squeeze a small amount (approximately 1-2 pea-size drops) onto your hand.
- Apply evenly to the entire face, or as directed by your skin care physician.
- If no improvement is seen after three (3) months of treatment, use of this product should be discontinued.
- For external use only
- Sun exposure should be limited by using a sunscreen agent or protective clothing to cover skin when using and after using this product in order to prevent darkening from reoccurring.
- Contains sodium metabisulfite, a sulfite that may cause allergic-type reactions, including anaphylactic symptoms and life-threatening or less severe asthmatic episodes in certain susceptible people. The overall prevalence of sulfite sensitivity in the general population is unknown and probably low. Sulfite sensitivity is seen more frequently in asthmatic than in non-asthmatic people.
- Please see above for additional important safety information
- Please click here for full Prescribing Information
- Store at controlled room temperature: 15°–25°C (59°–77°F)
- Keep out of direct sunlight


