search:
Home

RESOURCE CENTER

HOW SKIN AGES

OBAGI NU-DERM SYSTEM
Clinicals
Before & Afters
Testimonials
Products
Protocols
What to Expect
Questions and Answers
Clinical Posters

OBAGI-C Rx SYSTEM

OBAGI PROFESSIONAL-C SERUM

OBAGI BLUE PEEL SYSTEM

OBAGI CLENZIDERM M.D.

OBAGI ELASTIderm DÉCOLLETAGE

OBAGI CONDITION & ENHANCE

TESTIMONIALS

OUR HISTORY

 		For PatientsFor PhysiciansFor Skin Care SpecialistsAbout Obagi System

The Obagi Nu-Derm System® Demonstrates
Superior Clinical Results





Introduction: This 24-week study in 301 subjects examined the clinical efficacy and safety of a proprietary system (Obagi Nu-Derm System) composed of a specific protocol of cleanser, toner, alpha-hydroxy acid, tretinoin, hydroquinone and SPF (Group 1), compared with a 0.1% tretinoin regimen, including cleanser and SPF 30 (Group 2), 4.0% hydroquinone regimen, including cleanser and SPF 30 (Group 3) and the most common over-the-counter (OTC) products recommended by physicians - cleanser, moisturizer and SPF 30 (Group 4).

Methods: Facial photodamage (perioral wrinkles, periocular wrinkles, facial wrinkles, hyperpigmentation, clarity, sallowness, tactile roughness and laxity) and irritation (erythema, edema, scaling, papular rash, burning, stinging, itching and tightness) were assessed by investigative clinical graders at baseline and 1, 6, 12, 18 and 24 weeks of treatment. Digital photography, ultrasound scans, silicone replicas and full-thickness facial biopsies were also performed.

Results: Obagi Nu-Derm System was significantly more effective (P²0.05) than the other three treatments in all seven variables as demonstrated by change from baseline in evaluations at 12 weeks and 24 weeks (Figures 1 and 2).

Conclusions: Obagi Nu-Derm System outperformed the other three regimens (drug or OTC) at both 12 weeks and 24 weeks.

Conclusions


 Obagi Nu-Derm System significantly improved perioral fine wrinkles, periocular fine wrinkles, facial fine wrinkles, mottled hyperpigmentation, clarity, sallowness, tactile roughness and laxity compared with the commonly prescribed regimens of tretinoin and hydroquinone and the over-the-counter (OTC) regimens.

Obagi Nu-Derm System composed of a protocol of cleanser, toner, alpha-hydroxy acids with 0.1% tretinoin, 4.0% hydroquinone and SPF has statistically superior efficacy in the treatment of photodamage than other tested therapies.

Obagi Nu-Derm System was well tolerated when used under appropriate supervision.

Other efficacy parameters will be described in a future publication.

To optimize outcomes in individuals with fine lines and wrinkles plus laxity characteristic of photodamaged skin, clinicians should consider treatment with drug regimens or more ideally, with Obagi Nu-Derm System.

* To Read Details on this study click here.