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OBAGI® MEDICAL PRODUCTS, INC. LAUNCHES
CLENZIDERM M.D.TM PENETRATING ACNE THERAPUTIC SYSTEM
THERAPUTIC SYSTEM

New Acne System Clinically Proven to Provide Best-in-Class Penetration and Efficacy

Long Beach, California — February 2, 2007 — Obagi Medical Products, Inc. (NASD:OMPI), the leader in skin transformation, today announced the launch of a breakthrough acne therapy skincare line of topical products – CLENZIderm M.D.™ Acne Therapeutic System. The new acne kit boasts an advanced, patented Soluzyl Technology™ that liquefies Benzoyl Peroxide (BPO) on contact, which helps to deliver greater follicular penetration and rapid lesion reduction. The science validating the system will be the subject of two posters at the American Academy of Dermatology (AAD) convention in Washington D.C., beginning February 2, 2007.

“We are very excited to bring novel and efficacious technology to the field of acne treatment, a market valued at $XX million,” said Steven Carlson, President of Obagi. “Studies indicate that no other single acne treatment or combination therapy is proven to work on all three causes of acne, including excess oil, acne-causing bacteria and clogged pores. We believe this scientific breakthrough represents a transformation in the acne category and firmly establishes a new market opportunity for Obagi science.”

The CLENZIderm M.D.™ Acne Therapeutic System uses a combination of salicylic acid and a new, revolutionary gel form of BPO that allows for deeper penetration to control acne quickly. Most BPO’s are formulated with insoluble macro-crystals that, when applied, remain largely on the surface of the skin because they are too big to penetrate its surface. Obagi’s patented Soluzyl Technology™ liquefies the BPO on the surface of the skin for greater follicular penetration.

CLENZIderm M.D.™ Acne Therapeutic System will be previewed at the AAD accompanied by posters detailing the comparison of BPO/Clindamycin combination vs. CLENZIderm M.D.™ Acne Therapeutic System. The posters highlight the fact that consistent use of CLENZIderm M.D.™ Acne Therapeutic System results in a greater reduction of follicular acne in as early as eight hours and demonstrates both a 52% reduction in inflammatory lesions and a 34% reduction in non- inflammatory lesions in two weeks. CLENZIderm M.D.™ Acne Therapeutic System has also shown 80% patient satisfaction by improving the appearance of acne through the rapid clearing of lesions.

CLENZIderm M.D.™ Acne Therapeutic System is easy to use, highly effective and addresses the challenge of achieving superior patient-compliance results. Each step in the CLENZIderm M.D.™ Acne Therapeutic System is designed to complement one another. The Daily Care Foaming Cleanser is used to first remove excess sebum from the skin. The Pore Therapy acts as an exfoliator and removes dead skin cells, priming the skin for the application of the BPO. Lastly, the Serum Gel, containing the Soluzyl Technology™ and BPO, accelerates follicular penetration by delivering medication deep into the pores.

CLENZIderm M.D.™ Acne Therapeutic System products will retail as a kit and will be available in dermatologists’ and plastic surgeons’ offices nationwide beginning February 2007.

About Obagi Medical Products, Inc.
Obagi, a leader in the physician-dispensed skin care channel develops and commercializes skin health products for the dermatology, plastic surgery, and related Aesthetic markets. Using its Penetrating Therapeutics™ technologies, Obagi’s products are designed to improve penetration of agents across the skin barrier for common and visible skin conditions in adult skin such as chloasma, melasma, senile lentigines, acne vulgaris and sun damage. Obagi launched its first skincare system, Obagi Nu-Derm, in 1988; and in 2004 launched the first and only prescription strength Vitamin C and hydroquinone system, Obagi-C Rx. Obagi System products are only available through physicians. Visit www.obagi.com for information.